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in vitro/vivo Pharmacokinetic Screening

Harnessing proven technology and high quality SCAS provides in vitro/vivo pharmacokinetic screening services with fast delivery times.

Features

A full range of in vitro/vivo pharmacokinetic screening services for the drug discovery stage.
Regular screening, spot screening or other types are available to meet our customer's requirements.
Please inquire for details regarding customization of test conditions.

Testing

In vitro assessment items
Metabolic stability tests Calculation of remaining percentage in various animal species
Animals: humans/rats/mice/dogs/monkeys
Reactive metabolite tests dGSH trapping studies, GSH trapping studies
Enzyme inhibitor tests Cocktail substrate assay
Assessed molecules: CYP1A2/2B6/2C8/2C9/2C19/2D6/3A4
Enzyme induction tests Enzyme induction assessment in cryopreserved human hepatocytes (activity, mRNA expression)
Enzyme induction assessment using immortalized hepatocytes
Assessed molecules: CYP1A2/2B6/3A4, etc.
Protein bonding tests Equilibrium dialysis, ultracentrifugal method, ultrafiltration method
High-speed screening method
Membrane permeability tests Caco-2 cells, MDCK II cells
PAMPA
Transporter testing P-gp affinity assessment, inhibition assay (MDR1-MDCK II cells)
P-gp and BCRP assessment using Caco-2 cells
SLC transporter assessment test
Hepatic clearance prediction Cryopreserved hepatocytes floatation method, monolayer culture method
Chemical property assessments Solubility・logD
In vivo assessment items
Exploratory PK tests Measurement of drug concentration in blood plasma or tissue of various animals using LC-MSMS method. Dosage and concentration measurements for mice and rats can be conducted as a package.
Quantitative analysis of endogenous compounds Measurement of endogenous compounds in blood plasma or tissue of various animals. Includes steroid hormones, lipids, nucleic acids, amino acids and peptides. Can be used for biomarker searches or toxicity and drug efficacy assessments.

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Contact Us for Services

For inquiries and requests concerning services of analysis, measurements, products and consulting , please feel free to contact us via inquiry form or telephone/fax .

Telephone
+81-3-5689-1219
FAX
+81-3-5689-1222