Harnessing proven technology and high quality SCAS provides in vitro/vivo pharmacokinetic screening services with fast delivery times.
Features
A full range of in vitro/vivo pharmacokinetic screening services for the drug discovery stage.
Regular screening, spot screening or other types are available to meet our customer's requirements.
Please inquire for details regarding customization of test conditions.
Testing
| In vitro assessment items | |
|---|---|
| Metabolic stability tests | Calculation of remaining percentage in various animal species Animals: humans/rats/mice/dogs/monkeys |
| Reactive metabolite tests | dGSH trapping studies |
| Enzyme inhibitor tests | Cocktail substrate assay Assessed molecules: CYP1A2/2B6/2C8/2C9/2C19/2D6/3A4 |
| Enzyme induction tests | Enzyme induction assessment in cryopreserved human hepatocytes (activity, mRNA expression) Assessed molecules: CYP1A2/2B6/3A4 |
| Protein bonding tests | Equilibrium dialysis, ultracentrifugal method, ultrafiltration method High-speed screening method |
| Membrane permeability tests | Caco-2 cells, MDCK II cells PAMPA |
| Transporter testing | P-gp affinity assessment, inhibition assay (MDR1-MDCK II cells) |
| Chemical property assessments | Solubility・logD |
| In vivo assessment items | |
|---|---|
| Exploratory PK tests | Measurement of drug concentration in blood plasma or tissue of various animals using LC-MS/MS method. Dosage and concentration measurements for mice and rats can be conducted as a package. |
| Quantitative analysis of endogenous compounds | Measurement of endogenous compounds in blood plasma or tissue of various animals. Includes steroid hormones, lipids, nucleic acids, amino acids and peptides. Can be used for biomarker searches or toxicity and drug efficacy assessments. |
Technical News
-
TN526In Vitro Skin Permeation Test
-
TN397Evaluation of CYP Induction Using HepaRG® Cells
-
TN396Metabolic Stability in Hepatocytes
-
TN282Rapid Screening of Protein Binding
-
TN394Development of in vitro CYP Induction Assay Using Cryopreserved Human Hepatocytes
-
TN439Cytochrome P451 Inhibition Assays Using Cocktail Probe Substrates in vitro
-
TN415Rapid Screening of Reactive Metabolites Using Dansyl Glutathione
-
TN393P- glycoprotein Substrate and Inhibition Assay Using MDR2-MDCKⅡCells
-
TN382Permeability Evaluation Using Caco-3 cells for Assessment of Oral Absorption of Drugs
-
TN283Rapid Screening of Metabolic Stability in Liver Microsomes
Contact Us for Services
For inquiries and requests concerning services of analysis, measurements, products and consulting, please contact us via inquiry form.