Guard Filters SUMIPAX Filter｜HPLC Columns｜Instruments, Products & Synthesis

Porous glass filter to extend the lifetime of column without changing its separation performance

SUMIPAX Filter (for analysis) is a guard column which houses a 4 mmφ × 4 mmL cylindrical glass filter with 2-μm through holes. When a sample is analyzed using HPLC, performance of separation column decreases because:

substances contained in the sample are adsorbed at the column entrance, and chemically modify the surface of packing materials; and/or,
minute dust generated from pump, injector, etc. accumulates in the column, and gradually modifies the column physically.

SUMIPAX Filter is a filter with guard column functions. By inserting before a column, it prevents deterioration of the column.

SUMIPAX Filter dimensions and bonded phase

SUMIPAX Filter dimensions

	Dimensions, construction	Pressure drop at flow rate in the parenthesis	Internal diameter of compatible columns	Flow rate range
SUMIPAX Filter Anlytical	Length4mm Diameter4mm	About0.1 MPa（ 1mL/min） About0.8 MPa（10mL/min）	4, 4.6, 6, 8, 10	0.2 mL/min～ 10.0 mL/min
SUMIPAX Filter Semi-micro	Length2mm Diameter2mm	0.1MPa（0.2mL/min） About 0.4 MPa（2mL/min）	1, 2, 3, 4,4.6, 6	0.05 mL/min～ 2.0 mL/min

＊Mobile phase: methanol/water (1/1)

SUMIPAX Filter bonded phase

	Filter substrate	Compatible columns	Applicability
SUMIPAX Filter PG-ODS	Porous glass substrate treated with ODS and then endcapped	ODS columns Optical isomer separation columns SUMICHIRAL OA series	First selection for a wide range of diverse compounds. Applicable for both reversed-phase systems and normal phase systems.
SUMIPAX Filter PG-OH	Porous glass substrate as received	Silica gel columns Optical isomer separation columns SUMICHIRAL AGP、CBH、HSA	Highly hydrophobic or highly adsorbable compounds Protein-based chiral stationary phases

Application of SUMIPAX Filter

Analytical HPLC filters

Semi-micro HPLC filters

Applications of semi-micro HPLC by connecting with SUMIPAX Filter PG-ODS (for semi-micro HPLC) are shown below. No change is observed on chromatograms before and after connection. Semi-micro HPLC filters are also useful for LC-MS.

SUMIPAX　Filter　HB　（hybrid-type）

The SUMIPAX Filter HB is line-upped for ultra high performance liquid chromatography

Features of SUMIPAX Filter HB

The dual layer structure improves the particulate capture effect of the filter
⇒　By combining porous glass and sintered metal filter, the particulate capture rate is drastically improved compared to when one of them is used uncombined.

Deactivation of porous glass　⇒　Glass surface is treated with ODS and endcapping
Maximum filter pressure　⇒　50 MPa
Low cost replacement filter　⇒ Excellent running cost performance

Particulate capture effect

Silica particulates were injected into a column fitted with a filter and the change in the column pressure was observed and compared.

Filters	glass filter sintered metal filter HB filter (hybrid-type)
HPLC conditions	column Filter　＋　SUMIPAX ODS Z-CLUE　4.6×150mm mobile phase 20mmol／L　ammonium acetate aqueous solution/methanol （80：20）、 flow rate 0.8ｍｌ／min samples of injection silica particulates　0.1μm、20μg/inj

Fig. 1 Column pressure versus the number of injections in case of using only a glass filter

Fig. 2 Column pressure versus the number of injections in case of using only a sintered metal filter

When only a glass filter or only a sintered metal filter is used the column pressure barely increased after over 300 injections, indicating that the silica particles added to the mobile phase were not filtered out by the glass filter or the sintered metal filter and also passed through the column. Each filter is incapable of filtering out (capturing and eliminating) 0.1-μm silica particles by itself.

HB filter (hybrid type) has much more improved particulate capturing performance through its dual layer structure with glass filter and sintered metal filter. By connecting before a column, it extends the lifetime of the column. HB filter is particularly effective in protecting ultra-high performance LC columns.

Product list

SUMIPAX Filter for analytical HPLC

Product name	Product discription	Product code
SUMIPAX　Filter Starter kit PG-ODS	SUSholder 1、 filters 1	GAODS001
SUMIPAX　Filter PG-ODS【Replacement filters】	Replacement filtersー 3	GAODS003
SUMIPAX　Filter Starter kitPG-OH	SUS holder 1、filters 1	GA-OH001
SUMIPAX　Filter PG-OH【Replacement filters】	Replacement filters 3	GA-OH003
SUMIPAX　Holder	SUS holder 1	GAACC001
Connection kit	Ferrule screws 2、PEEK tube 1	GAACC002

SUMIPAX Filter for semi-micro HPLC

Product name	Product discription	Product code
SUMIPAX　Filter Starter kit PG-ODS	SUS holder 1、Filter 1	GMODS001
SUMIPAX　Filter PG-ODS【Replacement filters】	Replacement filters 3	GMODS003
SUMIPAX　Filter Starter kit PG-OH	SUS holder 1、Filter 1	GM-OH001
SUMIPAX　Filter PG-OH【Replacement filters】	Replacement filters 3	GM-OH003
SUMIPAX　Holder	SUS holder 1	GMACC001
Connection kit	Ferrule screws 2、PEEK tube 1	GMACC002

SUMIPAX Filter HB (UHPLC)

Product name	Product discription	Product code
SUMIPAX　Filter HB Starter kit	SUS holder 1、Filter 1	GHODS001
SUMIPAX　Filter HB【Replacement filters】	Replacement filters 3	GHODS003
SUMIPAX　Holder (UHPLC）	SUS holder 1	GUACC001

Catalog list

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Guard Filters SUMIPAX Filter