Comprehensive Biomarker Analytical Services from Drug Discovery through Clinical Development
Sumika Chemical Analysis Service, Ltd. (SCAS) provides comprehensive analytical support for the screening of biomarkers related to diseases, pharmacological activities, and toxicity; the development of accurate and reliable analytical methods; and analytical testing of samples in response to your requests.
Features
- We can analyze various endogenous compounds, including small molecules, peptides, DNA/RNA, proteins, and cells.
- We analyze protein biomarkers using the most appropriate analytical method, tailored to your objectives (e.g., coverage, quantitative performance), mainly employing ligand binding assay (LBA).
- For extracellular vesicles (EVs), including exosomes, as well as circulating tumor cells (CTCs) in blood, we perform their recovery, purification, and quality evaluation from blood samples for liquid biopsy applications, and we conduct biomarker analyses using these entities..
- Analytical methods can be flexibly customized according to your research objectives and the characteristics of your sample matrix.
Note: These services are intended for research use only and are not available for diagnostic purposes.
Biomarker Analysis Instrumentation
| Analysis Targets | Analysis Items | Methods and Instruments |
|---|---|---|
| Proteins | Proteomics | ELISA, ECL, Luminex, FCM |
| Peptides | Quantitative analysis | LC-MS/MS |
| Genes (DNA, RNA) |
DNA/RNA analysis | qPCR, ddPCR, NGS |
| Endogenous small molecules | Metabolomics | LC-MS/MS, GC-MS/MS |
| Cells | Immunophenotyping | Cell sorter, Beads assay, ECL, FCM |
| Circulating tumor cells (CTC), Extracellular vesicles (EVs, exosomes) | Quantitative analysis | FCM, ELISA, ECL |
Abbreviations:
- ELISA: Enzyme-Linked Immunosorbent Assay
- ECL: Electrochemiluminescence
- FCM: Flow Cytometry
- qPCR: Quantitative Polymerase Chain Reaction
- ddPCR: Droplet Digital Polymerase Chain Reaction
- NGS: Next Generation Sequencing
- LC-MS/MS: Liquid Chromatography–Tandem Mass Spectrometry
- GC-MS/MS: Gas Chromatography–Tandem Mass Spectrometry
LBA Analysis Solutions for Protein Biomarkers
Concept
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